My institution currently limits payment methods to Cybersource Hosted Order Page (HOP), so we do not at all take credit card information directly. This method requires an offsite payment as described here:
http://www.drupalcommerce.org/specification/apis/payment-methods

To use the HOP, the site will do a form submission to a 3rd party website. In this case it is a Cybersource-hosted web form for credit card or other payment. When the transaction is complete there, the transaction status information is returned back to the original store site.

I can currently do this with Ubercart, although the support for this was not initially built into the code. I have not used the HOP for more than traditional credit card payments, but Cybersource also supports e-checks and subscriptions.

For those interested, here is some information on the HOP.
http://apps.cybersource.com/library/documentation/dev_guides/HOP_UG/Host...

Is anyone working on this today?

Thanks,

-dave